Topics : Role of calcium signaling in Physiology and human physiopathology

With a Master’s degree in Physiology and Cellular Biology (specializing in electrophysiology) from the University of Poitiers, my research focuses on calcium signaling in cell physiology and pathology. My early work addressed calcium dynamics during myogenesis, particularly the regulation of myoblast fusion, as well as actin cytoskeleton remodeling mediated by calcium-dependent actin-binding proteins (Ghent University).

Since joining the CNRS, I have investigated the interplay between the cytoskeleton and calcium signaling in skeletal muscle cells, identifying key roles for dystrophin in regulating calcium homeostasis and ion channel function. This work led to studies on TRPC channels and their regulation by α-syntrophin, highlighting the contribution of calcium dysregulation to Duchenne muscular dystrophy and demonstrating the potential of mini-dystrophin for gene therapy approaches.

My research has expanded to cancer and stem cell biology through collaborations on actin signaling and cell migration in response to semaphorins and BCR-ABL. Since 2014, I have focused on calcium channels in adult neural stem cells as well as in cancer stem cells, investigating store-operated calcium entry and the role of calcium channels in glioma stem cell self-renewal and invasion. I have also contributed to projects on TRP channels in invasive cancer cell migration across various cancer models.

https://www.researchgate.net/profile/Bruno-Constantin